Ruta graveolens L. Induces Death of Glioblastoma Cells and Neural Progenitors, but Not of Neurons, via ERK 1/2 and AKT Activation
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منابع مشابه
Ruta graveolens L. Induces Death of Glioblastoma Cells and Neural Progenitors, but Not of Neurons, via ERK 1/2 and AKT Activation
Glioblastoma multiforme is a highly aggressive brain tumor whose prognosis is very poor. Due to early invasion of brain parenchyma, its complete surgical removal is nearly impossible, and even after aggressive combined treatment (association of surgery and chemo- and radio-therapy) five-year survival is only about 10%. Natural products are sources of novel compounds endowed with therapeutic pro...
متن کاملRuta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival.
BACKGROUND Ruta graveolens is a medicinal herb that has been used for centuries against various ailments. This study examined the anticancer properties of the herb using cancer cell lines. MATERIALS AND METHODS Methanolic extract of R. graveolens was tested on colon, breast and prostate cancer cells. Viability, cell cycle profiles, clonogenicity and capase activation were measured. Induction ...
متن کاملSulfasalazine induces autophagic cell death in oral cancer cells via Akt and ERK pathways.
Sulfasalazine (SSZ) is an anti-inflammatory drug that has been used to treat inflammatory bowel disease and rheumatoid arthritis for decades. Recently, some reports have suggested that SSZ also has anti-cancer properties against human tumors. However, little is known about the effects of SSZ on oral cancer. The aim of this study was to investigate the anti-cancer effects of SSZ in oral squamous...
متن کاملexistence and approximate $l^{p}$ and continuous solution of nonlinear integral equations of the hammerstein and volterra types
بسیاری از پدیده ها در جهان ما اساساً غیرخطی هستند، و توسط معادلات غیرخطی بیان شده اند. از آنجا که ظهور کامپیوترهای رقمی با عملکرد بالا، حل مسایل خطی را آسان تر می کند. با این حال، به طور کلی به دست آوردن جوابهای دقیق از مسایل غیرخطی دشوار است. روش عددی، به طور کلی محاسبه پیچیده مسایل غیرخطی را اداره می کند. با این حال، دادن نقاط به یک منحنی و به دست آوردن منحنی کامل که اغلب پرهزینه و ...
15 صفحه اولVolatile Composition of Ruta graveolens L. of North of Iran
The chemical constituents of the essential oil of Ruta graveolens L. from aerial parts collected from Iran were analyzed by GC and GC/MS. The oil yield of the dried plant obtained by hydrodistillation was 0.4% (v/w). Nineteen compounds, representing for 95.2% of the oil, were identified. The main classes of compounds were found to be ketons(46.6%) and sesquiterpenoids (13.3%) and monoterpenoids...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0118864